Two years after the bachelor party in Las Vegas, Phil, Stu, Alan, and Doug jet to Thailand for Stu's wedding. Stu's plan for a subdued pre-wedding brunch, however, goes seriously awry.
A shy student trying to reach his family in Ohio, and a gun-toting tough guy trying to find the Last Twinkie and a pair of sisters trying to get to an amusement park join forces to travel across a zombie-filled America.